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New research suggests potential combination therapy option for children with neuroblastoma to prevent resistance to treatment
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New research suggests potential combination therapy option for children with neuroblastoma to prevent resistance to treatment

New research published by Professor Suzanne Turner and led by Dr Perla Pucci in her group at the University of Cambridge Department of Pathology and CRUK Cambridge Centre Paediatric Cancer Programme, has suggested a new target for combination treatment of neuroblastoma and other cancers alongside ALK tyrosine kinase inhibitors (ALK TKI). Resistance to ALK TKI is a challenge and so additional targets for treatments that can be used in combination with ALK TKI are urgently needed.

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Encouraging results from the study investigating the role of Enhancer of Zeste homolog 2 (EZH2) and Natural Killer cells in Neuroblastoma

In 2023, Dr Gao, working with Prof Juliet Gray and Dr Zoë Walters at the University of Southampton, aimed to determine the role of natural killer cell- mediated anti-tumour effects in neuroblastoma, after treatment with EZH2. The objectives of the study were to look at the correlation between EZH2 protein expression and the surface expression of natural killer ligands in neuroblastoma cells, and to determine if the natural killer cells induced cytotoxicity that could be enhanced in the neuroblastoma cell lines with EZH2 inhibitors.

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Big donations for the Big Give Christmas Challenge

For the first time, Neuroblastoma UK took part in the Big Give Christmas Challenge 2023. We raised a grand total to £8,602 in just seven days.

We were blown away by everyone’s support, thank you. The money raised from the Big Give Christmas Challenge will enable scientists to take crucial first steps on the road of discovery - and help get closer to a cure for neuroblastoma.

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Chefs and celebrities share recipes to help children with neuroblastoma
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Chefs and celebrities share recipes to help children with neuroblastoma

Alan Carr and the UK’s favourite chefs including Jean-Christophe Novelli, Marcus Wareing and Monica Galetti share exclusive recipes to help children with neuroblastoma.

To mark Childhood Cancer Awareness Month, some of the UK’s top chefs are sharing exclusive recipes for you to treat your guests, when you a host a Get Together this September.

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Limited edition bracelet to help little warriors fighting neuroblastoma
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Limited edition bracelet to help little warriors fighting neuroblastoma

South of the River, a fashion boutique based in Beckenham, Kent, is supporting Neuroblastoma UK this summer with a limited edition ‘Warrior’ Tile Bracelet.

Inspired by children with cancer and designed in collaboration with Neuroblastoma UK, each bracelet features white ‘Warrior’ tiles on a yellow and gold bracelet with blue highlights.

South of the River will donate £3 from every ‘Warrior’ tile bracelet purchase to Neuroblastoma UK.

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